Urine Formaldehyde: A Non-Invasive Marker for Alzheimer’s Disease?
نویسنده
چکیده
Although Alzheimer’s disease (AD) characterized by progressive deterioration in cognitive function was first described over 100 years ago, there is still no suitable biomarker for diagnosing AD in easily collectable samples (e.g. blood plasma, saliva and urine). Stroke patients often suffer from post-stroke cognitive impairment, or even from post-stroke dementia (PSD) [1]. Recently, excess formaldehyde accumulated in the hippocampi has been found in both AD patients and several transgenic AD-like animal models [2]. Surprisingly, excess formaldehyde not only induces the aggregation of Aβ and Tau proteins in vitro [3,4] and in vivo [5,6], but also leads to vascular damage in patients with stroke, AD [3,7] and PSD [8-10]. These data strongly suggest that accumulated formaldehyde plays a critical role in cognitive decline.
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